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NSAIDs Overview

Non-steroidal anti-inflammatory drugs (NSAIDs) work great to reduce inflammation and pain. Ibuprofen and other COX-inhibitors belong to this group, but there are several negative effects of these drugs:

  • COX-inhibitors slow down the rate of protein synthesis…which negatively effects muscle tissue repair.
  • COX-inhibitors almost completely stop the function of tenocytes, which are the cells in the body that produce packed, arrayed collagen, the material that becomes connective tissue, tendons, ligaments, etc.
  • COX-inhibitors impede bone re-calcification so are not good for fractures or bone healing.
  • There is a negative effect of short-term administration of the cox-2 inhibitor parecoxib on fracture healing.
  • There is a negative effect of short-term administration of the cox-2 inhibitor parecoxib and the conventional NSAID indomethacin on the earlier fracture healing process.
  • There is a negative effect of short-term administration of the cox-2 inhibitor parecoxib and the conventional NSAID indomethacin on tendon healing.
  • There is a negative effect of short-term administration of the cox-2 inhibitor parecoxib and the conventional NSAID indomethacin on tendon-to-bone healing.

Dr. Sigbjorn Dimmen did research on these issues and documented them in his article, “Effects of Cox Inhibitors on Bone and Tendon Healing,” Click here to see excerpts of his study.

Additionally, NSAIDs have now been shown to increase oxidative stress in the body which can result in physiological chemical trauma, systemic inflammation, and a general decline in health.

Dr. Steven McAnulty did research on this and you can find information on his study here.

Other potential and well-known harmful effects of NSAIDs are:

  • COX-inhibitors are well known to be nephro-toxic. They are quite damaging to the renal cells of the body, and chronic use can result in enough kidney damage to require dialysis, and in some cases, kidney transplant.
  • COX-inhibitors are well known to cause G.I. ulcerations and stomach bleed if used frequently.
  • NSAIDs may cause asthma patients to be at higher risk for having allergic reactions.
  • Elderly are often at a greater risk of experiencing the negative side effects of NSAIDs.
  • Some NSAIDs have caused concern over increased risk of heart and cardio-vascular issues.
  • NSAIDs have numerous drug interactions with other medications.
  • NSAIDs negatively affect kidney function (some cases progress to a need for dialysis or kidney transplant).
  • Some NSAIDs and prescription pain relievers can irritate the colon and/or cause constipation.