Patient Case Study – July 26, 2016
Medical Indication: Irritable Bowel Syndrome
Location: Tiffin, Ohio
Data Gathering: Patient interviews
Patient presented with nearly 20 years of irritable bowel syndrome (IBS) symptoms. During the time of chronic management patient attempted a variety of therapies, medications, and techniques to treat or assuage symptoms but condition progressively worsened, resulting in significant and undesirable lifestyle limitations. In May, 2016, patient began taking a holistic and non-toxic anti-inflammatory (AI) product for lower back pain but noticed after 3 days that IBS symptoms had changed (improved) compared to previous experience. Patient increased dosing regimen of the AI product and within 2 weeks, manifestation of IBS symptoms largely disappeared.
Irritable bowel syndrome is a common disorder that affects approximately 45 million Americans. Irritable bowel syndrome may cause diarrhea (sometimes uncontrollable), cramping, abdominal pain, bloating, gas, and/or constipation. IBS is a chronic condition that normally requires long term management. Unlike ulcerative colitis and Crohn’s disease, which are forms of inflammatory bowel disease, IBS doesn’t cause changes in bowel tissue or increase risk of colorectal cancer. Some people can control their symptoms by managing their diet, lifestyle and stress. Others need medication and counseling.
It’s not known exactly what causes irritable bowel syndrome, but a variety of factors play a role. Intestinal walls are lined with layers of muscle that contract and relax in a coordinated rhythm as they move food from your stomach through your intestinal tract to your rectum. If you have irritable bowel syndrome, the contractions may be weaker or stronger than normal, causing bowel distress. Abnormalities in the gastrointestinal nervous system also may play a role with erratic brain signals causing pain, diarrhea or constipation. Food, stress, hormones (women are twice as likely to have IBS), and other illnesses can trigger or exacerbate IBS.
Diagnosis of IBS generally involves ruling other conditions out and assessment under either the Rome criteria or the Manning criteria. Because it’s not clear what causes IBS, treatment focuses primarily on the relief of symptoms.
Patient suffered with severe bowel distress for almost 20 years. Patient had no family history or risk factors that would anticipate irritable bowel syndrome. Patient reported the condition began with bowel disorders occurring in the wake of eating greasy foods or green, leafy foods however it worsened over time to where for the 5-10 years, severe bowel distress ensued within 10 minutes of eating food of any type. Patient’s distress was marked by thin, watery, or oily excretions followed by a continued feeling of having “to go” even after just going. Often times the urge to go would be sudden and nearly uncontrollable. Consumption of alcohol always worsened the symptoms causing the following day to be dramatically worse than the normal level of bowel dysfunction. Over the years, the condition was treated with various anti-diarrhea medications, probiotics, yogurt, fiber supplements, herbs, antibiotics, vitamins, and diet control but received little to no benefit from any of the treatments. Patient was not treated with Alosetron (Lotronex) or Lubiprostone (Amitiza) which sometimes have limited efficacy in cases like this.
Patient began taking AminoActiv® (Vireo Systems, Inc.) for chronic lower back pain. The back pain abated with treatment, but patient reported that within 3 days of beginning the anti-inflammatory regimen (2 capsules, 2-3 times per day) the bowel condition was markedly and unexpectedly improved. Patient began taking 2 capsules 4 times per day and reported that after 2 weeks of this increased dosage regimen, symptoms of the bowel disorder were almost entirely alleviated. Most noticeably, it was observed that consumption of almost any food or beverage caused no negative bowel effects. Therapeutic effects for the patient have continued for over 4 months.
While more study is needed, and this case study is neither an endorsement of any product nor connected to any FDA-approved clinical studies, the positive clinical outcomes of this patient with an otherwise chronic condition that has been unresponsive to other treatments causes interest in the AminoActiv product as a possible therapy for IBS. Toxicity studies done involving the main active ingredient (submitted to the FDA) indicate that Amino Activ is safe and does not have any known contraindication or drug-drug interactions.
* Acknowledgements to the staff of The Mayo Clinic background information on IBS (see Mayo Clinic website)